Cited Dangers of Neem Oil (Azadirachta indica)

Azadirachta indica

Safety Issues
Based on its extensive traditional use, neem seems to be quite safe. However, formal safety testing has only

involved neem oil, the insecticide product made from the plant. While neem has been found adequately safe

for use as an insecticide, animal studies suggest that long-term oral use of neem oil might produce

toxic effects. 10,11

In addition, other animal studies suggest that whole neem extract (which includes more substances than neem

oil) may damage chromosomes, at least when taken in high doses or for an extended period of time. 3,12

For all these reasons, as well as the lack of comprehensive safety investigation of neem products

other than neem oil, we recommend that young children, pregnant or nursing women, or individuals

with severe liver or kidney disease avoid use of neem.

Halifax Health USA

3. Awasthy KS, Chaurasia OP, Sinha SP. Prolonged murine genotoxic effects of crude extracted from neem.               Phytother Res . 1999;13:81-83.

10. Rahman MF, Siddiqui MK, Jamil K. LDH profiles of male and female rats treated with Vepacide.
     Phytother Res. 2002;16:122-126.

11. Rahman MF, Siddiqui MK, Jamil K. Effects of Vepacide ( Azadirachta indica ) on aspartate and alanine              aminotransferase profiles in asubchronic study with rats. Hum Exp Toxicol. 2001;20:243-249.

12. Awasthy KS. Genotoxicity of a crude leaf extract of neem in male germ cells of mice.

     Cytobios. 2001;106 Suppl 2:151-164.